GVHD vs. Graft Rejection
- What are the pathophysiologic differences between graft versus host disease and graft rejection?
Graft versus Host Disease (GVHD) and graft rejection are both immune-mediated conditions that occur after transplantation, but they have distinct pathophysiological mechanisms. Here are the key differences:
1. Mechanism of Immune Attack
- Graft versus Host Disease (GVHD):
- Occurs when the donor immune cells (particularly T cells) recognize the recipient’s tissues as foreign and mount an immune response against them. This is primarily due to the activation of donor T cells, which can be stimulated by the recipient’s antigen-presenting cells.
- GVHD is most commonly seen in allogeneic stem cell transplants, where the donor’s immune system is introduced into a new environment (the recipient) and perceives the host tissues as targets…
Graft versus Host Disease (GVHD) and graft rejection are both immune-mediated conditions that occur after transplantation, but they have distinct pathophysiological mechanisms. Here are the key differences:
1. Mechanism of Immune Attack
- Graft versus Host Disease (GVHD):
- Occurs when the donor immune cells (particularly T cells) recognize the recipient’s tissues as foreign and mount an immune response against them. This is primarily due to the activation of donor T cells, which can be stimulated by the recipient’s antigen-presenting cells. GVHD vs. Graft Rejection
- GVHD is most commonly seen in allogeneic stem cell transplants, where the donor’s immune system is introduced into a new environment (the recipient) and perceives the host tissues as targets…
Graft versus Host Disease (GVHD) and graft rejection are both immune-mediated conditions that occur after transplantation, but they have distinct pathophysiological mechanisms. Here are the key differences:
1. Mechanism of Immune Attack
- Graft versus Host Disease (GVHD):
- Occurs when the donor immune cells (particularly T cells) recognize the recipient’s tissues as foreign and mount an immune response against them. This is primarily due to the activation of donor T cells, which can be stimulated by the recipient’s antigen-presenting cells.
- GVHD is most commonly seen in allogeneic stem cell transplants, where the donor’s immune system is introduced into a new environment (the recipient) and perceives the host tissues as targets…
