Protective Effects of GVHD
- Studies have shown a protective effect of mild to moderate GVHD in cancer patients who have had a bone marrow transplant. Based on your understanding, can you explain these findings?
The protective effect of mild to moderate Graft versus Host Disease (GVHD) in cancer patients following a bone marrow transplant can be understood through several interconnected mechanisms:
1. Graft Versus Tumor Effect (GVT)
- Mechanism: In the context of bone marrow transplants, especially allogeneic transplants, donor immune cells (particularly T cells) can recognize and attack residual cancer cells in the recipient’s body. This phenomenon is referred to as the Graft versus Tumor (GVT) effect.
- Role of GVHD: Mild to moderate GVHD indicates that the donor T cells are actively engaged in recognizing foreign antigens, which can include cancer-specific antigens. This immune response can lead to the elimination of cancer cells, providing a therapeutic benefit…
The protective effect of mild to moderate Graft versus Host Disease (GVHD) in cancer patients following a bone marrow transplant can be understood through several interconnected mechanisms:
1. Graft Versus Tumor Effect (GVT)
- Mechanism: In the context of bone marrow transplants, especially allogeneic transplants, donor immune cells (particularly T cells) can recognize and attack residual cancer cells in the recipient’s body. This phenomenon is referred to as the Graft versus Tumor (GVT) effect.
- Role of GVHD: Mild to moderate GVHD indicates that the donor T cells are actively engaged in recognizing foreign antigens, which can include cancer-specific antigens. This immune response can lead to the elimination of cancer cells, providing a therapeutic benefit…
The protective effect of mild to moderate Graft versus Host Disease (GVHD) in cancer patients following a bone marrow transplant can be understood through several interconnected mechanisms:
1. Graft Versus Tumor Effect (GVT)
- Mechanism: In the context of bone marrow transplants, especially allogeneic transplants, donor immune cells (particularly T cells) can recognize and attack residual cancer cells in the recipient’s body. This phenomenon is referred to as the Graft versus Tumor (GVT) effect. Protective Effects of GVHD
- Role of GVHD: Mild to moderate GVHD indicates that the donor T cells are actively engaged in recognizing foreign antigens, which can include cancer-specific antigens. This immune response can lead to the elimination of cancer cells, providing a therapeutic benefit…
